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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站

A |     Ahaan Panday and Aneet Padda have delivered one of the biggest blockbusters of this year, Saiyaara. The duo not only impressed the audience with their onscreen chemistry, but they also continue to remain good friends even off camera. Ahead of the film's World Television Premiere, the actors have opened up about their bond and why it felt so natural.     Ahaan said that there was no formula involved in creating the chemistry, and it was not engineered at all. He feels that when co-stars get along well, everything else happens naturally.          Ahaan said that there was no formula involved in creating the chemistry, and it was not engineered at all. He feels that when co-stars get along well, everything else happens naturally.     "I think when two people genuinely become great friends, you don’t have to plan the chemistry on screen...Whatever happens, happens naturally and effortlessly," Ahaan told LiveMint.     Aneet also opened up about her bond with Ahaan and said, "When I met Ahaan for the first time, I knew that I was going to be very comfortable with this person…There was something very disarming about him."          The actress shared that the first time she met director Mohit Suri and Ahaan together, she was nervous and was 'messing up a bit'. She revealed that she was cracking jokes that weren't laughing but Ahaan was still laughing.     "He played the guitar, we sang songs, chatted a lot in the car when he came to drop me home, and that’s when I thought he was a fantastic presence to be around. I really liked him and his energy," Aneet told LiveMint.She continued, "We became very good friends in the months before the shoot, met a lot, shared our doubts and fears." Aneet also revealed that she and Ahaan had each other's backs during the filming, and it made her feel safe and comfortable on set.     Saiyaara earned over Rs 500 crore worldwide. It is now streaming on Netflix.Also Read: Ahaan Panday and Aneet Padda Lead IMDb’s Most Popular Indian Stars of 2025 List。    

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Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. 
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. 
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. 
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. 
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. 
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
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