上锁的房间

Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站

一 |     8月15日，中国体育彩票“乐透开海狂欢夜”主题活动空降2026北部湾开海节，在防城港白浪滩景区掀起一场滨海狂欢。    

    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
。

二 | 体彩创新打造“体彩逐浪运动嘉年华”主题展区，将品牌展示、趣味互动、购彩体验与开海节上千帆竞发的出海盛况、歌舞演艺、潮玩开海大集与海鲜盛宴融为一体，不仅为开海盛会增添一抹公益亮色，更为滨海文旅消费场景注入全新活力。游客在趣味游玩中感受“迈开步 动出彩”的运动活力活动现场，体彩精心打造沉浸式特色展区，集品牌形象展示、趣味运动互动、顶呱刮彩票体验于一体。

三 | 游客在趣味游玩中感受“迈开步 动出彩”的运动活力，近距离触摸体彩背后温暖的公益底色。主舞台互动环节精彩纷呈，体彩互动问答、趣味挑战赛轮番上演，现场人气高涨、氛围火热。在体彩加油站，顶呱刮即开票吸引了众多年轻游客一试手气，刮一张彩票，成为许多人在海边邂逅的小期待。游客在体彩展区愉快体验顶呱刮即开票此外，体彩还将公益知识科普与体彩反诈知识巧妙融入游戏环节，寓教于乐，在轻松氛围中向市民、游客普及理性购彩理念。工作人员向游客科普体彩反诈知识与理性购彩理念近年来，"体彩+文体旅商"融合模式持续深化。此次体彩亮相北部湾开海节，不仅将公益品牌与滨海消费场景有机融合，更以多元互动形式让"理性购彩、随手公益"的理念触达更广泛人群。

四 | 据悉，此次北部湾开海节暨白浪风情嘉年华系列活动自8月14—23日在防城港白浪滩持续上演。

Current article:http://www.shangfochengcongshuaizhuang.buzz/list_s7e/u4eps.html

Published on:03:00:08